Related Experiment Video

Updated: May 29, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.6K

Achondroplasia and obstructive sleep apnea: surgical outcomes and comparison to general population

Claudio Gomez Ascencio1, Anna Wani1, Ron B Mitchell1

  • 1University of Texas Southwestern Medical Center, Dallas, Texas.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|February 6, 2025
PubMed

Insights

Children with achondroplasia and obstructive sleep apnea (OSA) experience earlier onset and benefit from adenotonsillectomy for moderate to severe OSA. Surgical interventions like cervicomedullary decompression also improved apnea-hypopnea index.

Area of Science:

  • Pediatric Sleep Medicine
  • Genetics and Rare Diseases
  • Surgical Outcomes

Background:

  • Achondroplasia is a genetic disorder characterized by disproportionate dwarfism.
  • Obstructive sleep apnea (OSA) is a common comorbidity in children with achondroplasia.
  • Understanding the demographics and treatment efficacy in this population is crucial.

Purpose of the Study:

  • To compare the demographics of children with achondroplasia and OSA to the general pediatric OSA population.
  • To evaluate the surgical treatment outcomes for children with achondroplasia and OSA.
  • To identify differences in age of onset and treatment response.

Main Methods:

  • Retrospective chart review of 22 children with achondroplasia and OSA and 141 controls with OSA.
  • Analysis of polysomnography parameters before and after surgical interventions.
  • Comparison of baseline characteristics between the achondroplasia and control groups.

Main Results:

  • Children with achondroplasia and OSA presented at a significantly younger age (3.1 years) for adenotonsillectomy compared to controls (6.8 years).
  • Adenotonsillectomy in achondroplasia patients with moderate to severe OSA led to improvements in obstructive apnea-hypopnea index and oxygen saturation.
  • Adenoidectomy alone did not significantly alter OSA, while cervicomedullary decompression improved the obstructive apnea-hypopnea index.

Conclusions:

  • Patients with achondroplasia and OSA exhibit an earlier age of onset compared to their non-achondroplasia counterparts.
  • Adenotonsillectomy is an effective treatment for moderate to severe OSA in children with achondroplasia.
  • Cervicomedullary decompression offers a potential benefit for improving OSA in this population.
Abstract

Keywords:
achondroplasiapediatricssleep apnea

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

685
Image Acquisition using Portable Sonography for Emergency Airway Management07:31

Image Acquisition using Portable Sonography for Emergency Airway Management

Published on: September 28, 2022

2.3K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
123
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
799
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
955