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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Assembly of the Lipid Bilayer in the ER01:28

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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Lipid-derived Compounds in the Human Body01:31

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
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Updated: May 29, 2025

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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Ceramides and Skin Health: New Insights.

Tze Lek Yong1, Rahela Zaman1, Navedur Rehman2

  • 1School of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia.

Experimental Dermatology
|February 6, 2025
PubMed
Summary

Ceramides are crucial for skin health, forming a moisture barrier and treating conditions like atopic dermatitis (AD). Research explores their potential in cancer therapy and diagnostics, with various methods to boost ceramide levels.

Keywords:
anti‐inflammatoryceramideskin barrier functionskin diseaseskin hydration

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Area of Science:

  • Dermatology and Biochemistry
  • Investigates the role of lipids in skin barrier function and disease pathology.

Background:

  • Ceramides are essential lipids for maintaining skin barrier integrity, hydration, and regulating inflammation.
  • Clinically used for inflammatory skin conditions like atopic dermatitis (AD) and dry skin.
  • Serve as biomarkers for disease prediction and diagnosis.

Purpose of the Study:

  • To explore the multifaceted role of ceramides in maintaining overall skin health.
  • To investigate the therapeutic applications of ceramides in common and severe skin diseases.
  • To review ceramide's potential in anti-cancer therapies and nanotechnology-based drug delivery.

Main Methods:

  • Literature review of pre-clinical and clinical studies on ceramide.
  • Analysis of ceramide's function in skin barrier repair and inflammation control.
  • Examination of ceramide's emerging roles in oncology and drug delivery systems.

Main Results:

  • Established benefits include moisture barrier creation, hydration, pH regulation, and anti-inflammatory effects.
  • Ceramides are effective in treating conditions like AD and psoriasis.
  • Pre-clinical studies show promise for ceramide in anti-cancer applications and as drug carriers.

Conclusions:

  • Ceramides are vital for skin health and treating common dermatological conditions.
  • Further research is needed to advance ceramide's application in severe conditions like skin cancer.
  • Approaches to increase ceramide levels include topical application, supplements, and analogues.