Clinico-etiological Profile and Metabolic Complications in Pediatric Early Onset Obesity - Experience from a Tertiary

Related Experiment Video

Updated: May 29, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.0K

Simran Syal1, Vrushali Takalikar2, Sudha Rao3

  • 1Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Raipur, India.

Indian Pediatrics
|February 6, 2025
PubMed

Insights

Primary obesity is common in young children. Parental obesity, increased screen time, and acanthosis nigricans are key risk factors for early onset obesity, indicating a mix of genetic and lifestyle influences.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Early onset obesity, presenting before age five, poses significant health challenges.
  • Differentiating primary from secondary obesity is crucial for appropriate management in young children.

Purpose of the Study:

  • To characterize the clinical and metabolic profiles of children with early onset obesity.
  • To identify risk factors and features distinguishing primary from secondary obesity in children under five.

Main Methods:

  • Retrospective analysis of medical records for children diagnosed with early onset obesity (June 2015-December 2023).
  • Evaluation of etiological diagnoses, risk predictors, laboratory profiles, and genetic studies.
  • Statistical analysis to determine associations between factors and obesity etiology.

Main Results:

  • Primary obesity was diagnosed in 71.4% of 77 children under five with obesity.
  • Genetic causes were identified in 18.18% of these children.
  • Increased screen time (>2 hours/day), acanthosis nigricans, and parental obesity were significantly associated with primary early onset obesity.

Conclusions:

  • Primary obesity is more prevalent in early onset cases.
  • Parental obesity, excessive screen time, and acanthosis nigricans are significant risk factors.
  • A combination of genetic predisposition and unhealthy lifestyle contributes to primary early onset obesity.
Abstract

More Related Videos

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

3.6K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.4K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
371
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
499
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
124
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
852
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K