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Updated: May 29, 2025
Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Enantioselective Decarboxylative Hydrogen-Atom Transfer Reaction
Yugui Xu1, Chaoren Shen1,2, Kaiwu Dong1,2
1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Abstract:
Direct enantioselective decarboxylative transformations of carboxylic acids have become powerful tools for constructing structurally and functionally diverse molecules. Herein, an unprecedented organocatalyzed protocol for enantioconvergent decarboxylative reduction was established by leveraging dual catalysis of photoredox-mediated radical generation and a thiol-catalyzed asymmetric hydrogen-atom transfer process. With this hydrodecarboxylation, a variety of chiral 3-substituted indolines were attained from the acids in moderate to excellent yields with high enantioselectivities.
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