Effect of estazolam plus remimazolam on attenuating preoperative anxiety and remifentanil-induced postoperative hyperalgesia in elective gynecological laparoscopic surgery: a randomized clinical trial
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View abstract on PubMed
Summary
This summary is machine-generated.Preoperative estazolam and remimazolam effectively reduced anxiety and postoperative pain in gynecological surgery patients. The combination therapy also significantly lowered opioid consumption, offering a promising approach to managing surgical pain.
Area Of Science
- Anesthesiology
- Pharmacology
- Pain Management
Background
- Preoperative anxiety is linked to increased opioid-induced hyperalgesia.
- High preoperative anxiety can worsen opioid-induced hyperalgesia.
- Gynecological laparoscopic surgery patients often experience preoperative anxiety and postoperative pain.
Purpose Of The Study
- To evaluate the impact of estazolam, remimazolam, and their combination on preoperative anxiety.
- To assess the effect of these agents on opioid-induced hyperalgesia and postoperative pain.
- To determine the efficacy in patients undergoing elective gynecological laparoscopic surgery.
Main Methods
- A randomized, double-blind, placebo-controlled trial involving 108 patients.
- Four groups received estazolam, remimazolam, both, or placebo.
- Outcomes included pain intensity, opioid consumption (sufentanil), and adverse events over 72 hours.
Main Results
- Estazolam, remimazolam, and their combination significantly reduced preoperative anxiety compared to placebo.
- The combination therapy led to significantly lower postoperative pain scores at multiple time points.
- Combined estazolam and remimazolam significantly reduced cumulative sufentanil consumption post-surgery.
Conclusions
- Preoperative estazolam and remimazolam alleviate anxiety and postoperative pain in gynecological laparoscopic surgery.
- The combined use of estazolam and remimazolam offers superior pain relief and reduced opioid requirements.
- This combination therapy presents a viable strategy for managing pain and anxiety in this patient population.
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