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Spinal Nerves: Plexus II

Spinal Nerves: Plexus II

The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...

Spinal Nerves: Plexus I

Spinal Nerves: Plexus I

Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...

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Related Experiment Video

Updated: May 29, 2025

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

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Published on: April 23, 2018

Acral Cutaneous Intraneural Pseudoperineurioma.

Badr AbdullGaffar¹, Rabiah Farhan

¹Pathology Section, Dubai Hospital, Dubai, United Arab Emirates .

The American Journal of Dermatopathology

|February 6, 2025

Summary

This study identifies unique hand nodules in teenagers, characterized by specific neurovascular and perineurial features. These findings suggest a distinct clinicopathologic entity, potentially a new type of pseudoperineurioma.

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Area of Science:

Dermatopathology
Histopathology
Oncology

Background:

Cutaneous neurovascular stromal lesions are poorly defined, leading to misdiagnosis.
Existing literature lacks comprehensive data on their prevalence and classification.

Purpose of the Study:

To elucidate the histopathologic, histochemical, and immunohistochemical characteristics of acral nodular tumors with perineuriomatous differentiation.
To establish a potential distinct clinicopathologic entity for these lesions.

Main Methods:

Analysis of 3 cases of hand nodules in teenagers from a larger cohort of 1331 patients.
Histopathologic examination using Masson trichrome, Alcian blue staining.
Immunohistochemical analysis with CD31, ERG, smooth muscle actin, CD34, S100, SOX10, neurofilament, EMA, and GLUT1.

Main Results:

Nodules showed dermal-based growths with tortuous neurovascular bundles and collagenous stroma.
Distinct perineurial differentiation (EMA, GLUT1 positive) within neurovascular bundles and onion-bulb structures.
Sparse neural components (S100, SOX10, neurofilament positive) were observed.

Conclusions:

The findings suggest cutaneous intraneural pseudoperineurioma nodules may be a distinct entity.
These lesions resemble cutaneous intraneural perineurioma but may differ.
Further validation and molecular studies are needed due to the small sample size.