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Updated: May 29, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Impact of new medications on the treatment of immune TTP
Marie Scully1, Lara Howells2, William A Lester3
1Department of Haematology, University College London Hospital, and Haematology Programme, National Institute for Health and Care Research Biomedical Research Centre at University College London Hospital, London, United Kingdom.
Abstract:
The last decade has seen the introduction of 2 new licensed therapies for thrombotic thrombocytopenic purpura (TTP), caplacizumab and recombinant ADAMTS13 (rADAMTS13), for immune and congenital TTP (cTTP), respectively. They improve acute TTP outcomes, and reduce the need for plasma therapy, time to clinical response, and treatment burden. Future pathways need to replace plasma exchange in acute TTP and optimize/personalize rADAMTS13 in cTTP. Future emphasis should focus on additional monoclonals/treatments to tackle ADAMTS13 antibodies.
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