Teens with Type 1 Diabetes and Executive Function Challenges Who Use Insulin Pumps Have Lower A1C Without Increased Risk of Diabetic Ketoacidosis or Severe Hypoglycemia
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View abstract on PubMed
Summary
This summary is machine-generated.Insulin pumps may improve glycemic control in teens with type 1 diabetes and executive function challenges. This study found lower A1c levels in pump users with executive function challenges, without increasing diabetic ketoacidosis risk.
Area Of Science
- Pediatric Endocrinology
- Metabolic Disorders
- Neuroscience
Background
- Type 1 diabetes self-management requires consistent executive function (EF).
- Executive function challenges can impede diabetes self-care in adolescents.
- Insulin pump therapy is an alternative to multiple daily injections for type 1 diabetes management.
Purpose Of The Study
- To evaluate the risks and benefits of insulin pump use in adolescents with type 1 diabetes and executive function challenges.
- To compare glycemic control (A1c) and adverse events (severe hypoglycemia, diabetic ketoacidosis) between insulin pump users and non-users in this population.
Main Methods
- Parent-reported executive function was assessed using the Behavior Rating Inventory of Executive Function.
- Prospective data collection of severe hypoglycemia and diabetic ketoacidosis events.
- Comparison of A1c levels and incidence rates of adverse events between pump users and non-users, stratified by executive function status.
Main Results
- Adolescents with type 1 diabetes and EF challenges using insulin pumps had significantly lower A1c levels (8.5% vs. 9.2%) compared to non-users.
- No significant difference in A1c was observed between pump users and non-users in adolescents without EF challenges.
- Diabetic ketoacidosis incidence was lower in pump users compared to non-users overall, and specifically in those without EF challenges, but not in those with EF challenges.
Conclusions
- Insulin pump therapy is associated with improved glycemic control in adolescents with type 1 diabetes and executive function challenges.
- Insulin pump use in this population did not increase the risk of diabetic ketoacidosis.
- Findings support the consideration of insulin pump therapy for adolescents with type 1 diabetes and executive function challenges, despite potential prescriber hesitancy.
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