Metal-Phenolic Network (MPN) Modified Janus Fibrous Hydrogel Scaffold for Infected Diabetic Wound Healing

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Diabetic wound management is complicated by edema-induced ischemia and traditional dressings that exacerbate infection.
• Hydrophilic dressings retain exudate, promoting bacterial growth and delaying healing.

Purpose of the Study:

• To design and evaluate a multifunctional double-layer Janus fibrous hydrogel for accelerated healing of infected diabetic wounds.
• To create a dressing with both hydrophobic and superhydrophilic properties to manage wound environment.

Main Methods:

• Fabrication of a bilayer Janus fibrous hydrogel with a hydrophobic outer layer (poly(vinylidene fluoride)/cellulose acetate) and a superhydrophilic inner layer (gelatin methacrylate/polycaprolactone coated with zinc-dopamine complex).
• Characterization of structural, physicochemical, mechanical, swelling, antioxidant, and antibacterial properties.
• In vivo evaluation using infected diabetic BALB/c mice to assess wound healing, bacterial invasion, and tissue regeneration.

Main Results:

• The hydrophobic outer layer demonstrated antifouling and self-cleaning properties, preventing microbial entry.
• The superhydrophilic inner layer exhibited significant antibacterial, antioxidant, and cell-supportive capabilities.
• In vivo studies showed the Janus hydrogel promoted wound reconstruction, angiogenesis, and collagen deposition.

Conclusions:

• The developed Janus fibrous hydrogel effectively manages infected diabetic wounds by controlling exudate and infection.
• This advanced wound dressing shows significant potential for promoting tissue regeneration and improving diabetic wound treatment outcomes.