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[Abnormal hemoglobins identified in Martinique].
Nouvelle Revue Francaise D'Hematologie
|January 1, 1985
Summary
Epidemiologic programs in Martinique identified frequencies of sickle cell (Hb S), Hb C, and beta-thalassemia traits. Structural analysis of rare variants revealed pathological interactions, aiding genetic counseling.
Area of Science:
- Hematology
- Genetics
- Public Health
Context:
- Epidemiologic programs in Martinique over the past decade, especially the last five years.
- Focus on screening for hemoglobinopathies.
Purpose:
- Determine the frequencies of sickle cell (Hb S), Hb C, and beta-thalassemia traits.
- Detect and structurally analyze rare hemoglobin variants.
Summary:
- Screening identified Hb S, Hb C, and beta-thalassemia trait frequencies.
- Rare variants were detected and structurally analyzed.
- Pathological interactions with Hb S were observed for variants like Hb D Punjab and Hb O Arab.
Impact:
- Electrophoretic mobilities aid rapid presumptive identification of hemoglobin variants.
- Provides a valuable tool for genetic counseling and management of hemoglobinopathies.