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Updated: May 29, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Radiochemical Synthesis of Alkyl Geminal 18F-Difluoroalkyl Motifs Mediated by Silver(I) Oxide
Pawan Mishra1, Jasmine Hind1, Ian A Fallis1
1School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K.
Abstract:
18F radiotracers are used in positron emission tomography imaging for medical diagnosis and drug development. Current methods to synthesize 18F-polyfluorinated functional groups are limited in substrate scope and result in radiotracers with low molar activities (A). We disclose the synthesis of a range of 18F-difluoroalkyl groups by nucleophilic substitution of geminal bromofluoroalkyl electrophiles with [18F]fluoride mediated by Ag2O. The utility of this transformation to support (pre)clinical imaging is demonstrated by translation to an automated synthesizer.
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