Related Experiment Video
Updated: May 29, 2025

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
Published on: September 13, 2024
Simian virus 40 (SV40) - Fresh perspectives on a historic virus
Barry I Milavetz1, Lata Balakrishnan2
1Department of Biomedical Sciences, University of North Dakota, Grand Forks, North Dakota, 58202, USA.
Abstract:
Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. Recent advancements have shed light on several key processes. These include dissecting the stages leading to the transport of bound SV40 to the nucleus of the infected cell, understanding how chromatin structure contributes to the regulation of early and late transcription, characterizing the role of T-antigen during DNA replication, and determining how an SV40 infected cell is killed, and newly generated progeny viruses are released. Despite this progress, critical questions remain, including how the biological fates of chromosomes are determined and how functionally distinct chromosomes coexist in infected cells. This review discusses these recent advancements in SV40 biology.
More Related Videos
13:13Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
Published on: September 25, 2018
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Retrovirus Life Cycles
Retroviruses
Viral Mutations
Viral Recombination