Opposing and segregated cortical circuits control winning and losing behaviors
Elizabeth Illescas-Huerta1, Nancy Padilla-Coreano1
1Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Neuron
|February 6, 2025
Abstract:
In this issue of Neuron, Xin et al.1 reveal how the dorsomedial prefrontal cortex (dmPFC) orchestrates social dominance through subcortical pathways to the amygdala and brainstem. Using optogenetics and functional mapping, they identify opposing win- and lose-related circuits, uncovering a laminar organization driving competitive behavior in mice.
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