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Somatic CAG-repeat expansion drives neuronal loss in Huntington's disease
1Huntington's Disease Center and Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, London WC1N 3BG, UK.
Neuron
|February 6, 2025
Abstract:
Using single-cell technologies on postmortem brains, Handsaker et al.1 have demonstrated that substantial somatic expansion of the CAG repeat that causes Huntington's disease results in progressive transcriptional dysregulation and drives the loss of spiny projection neurons in the caudate.

