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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: May 29, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Nevoid melanoma.

Rodolfo Valentini1, Julia Quinn1, Michael J Murphy2

  • 1University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Clinics in Dermatology
|February 6, 2025
PubMed
Summary
This summary is machine-generated.

Nevoid melanoma, a rare and challenging skin cancer, often mimics benign moles, leading to delayed diagnosis. Advancements in diagnostic tools aid in earlier identification of this melanoma subtype.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Nevoid melanoma is a rare melanoma subtype.
  • It is difficult to diagnose due to its resemblance to benign nevi.
  • Delayed diagnosis can lead to adverse patient outcomes.

Purpose of the Study:

  • To understand the development and progression of nevoid melanoma.
  • To improve the identification of nevoid melanoma.
  • To highlight the impact of diagnostic delays.

Main Methods:

  • Dermatoscopy
  • Microscopy
  • Immunohistochemistry

Main Results:

  • Technological advancements have improved understanding and diagnosis.
  • Nevoid melanoma shares similarities with benign nevi.
  • Early diagnosis is crucial for better patient outcomes.

Conclusions:

  • Nevoid melanoma requires careful differentiation from benign lesions.
  • Advanced diagnostic techniques are essential for early detection.
  • Prompt diagnosis of nevoid melanoma is critical, despite its similar appearance to benign nevi.