Performance of Machine Learning Models in Predicting BRAF Alterations Using Imaging Data in Low-Grade Glioma: A...

Understanding the BRAF alterations preoperatively could remarkably assist in predicting tumor behavior, which leads to a more precise prognostication and management strategy. Recent advances in artificial intelligence (AI) have resulted in effective predictive models. Therefore, for the first time, this study aimed to review the performance of machine learning and deep learning models in predicting the BRAF alterations in low-grade gliomas (LGGs)using imaging data.

PubMed/MEDLINE, Embase, and the Cochrane Library were systematically searched for studies published up to June 1, 2024, and evaluated the performance of AI models in predicting BRAF alterations in LGGs using imaging data. Pooled sensitivity, specificity, and area under the receiver operating curve (AUROC) were meta-analyzed.

A total of 6 studies with 951 patients were included in this systematic review. The pooled AUROC of internal validation cohorts for their best-performing model was 84.44%, with models detecting BRAF mutation, BRAF fusion, BRAF fusion from mutation, and BRAF wild type producing similar AUROCs of 90.75%, 84.59%, 82.33%, and 82%, respectively. The best-performing models had pooled sensitivities of 80.3%, 87.51%, and 74.14% and pooled specificities of 88.57%, 70.41%, and 83.98% for detection of BRAF fusion from mutation, BRAF fusion, and BRAF mutation, respectively.

AI models may perform relatively well in predicting BRAF alterations in LGG using imaging data and appear to be capable of high sensitivities and specificities. However, future studies with larger sample sizes implementing different machine learning or deep learning algorithms are required to reduce imprecision.