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Home noninvasive ventilation in pediatric patients: Does one size fit all?
Sonia Khirani1, Lucie Griffon2, Alessandro Amaddeo3
1ASV Santé, F-92000, Gennevilliers, France; Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, F-75015, Paris, France; Université de Paris Cité, EA 7330 VIFASOM, F-75004, Paris, France.
Insights
Continuous positive airway pressure (CPAP) and non-invasive ventilation (NIV) settings in children increase with age. While CPAP/NIV settings vary by age, they are generally similar across different pediatric disorders, emphasizing individual adaptation.
Area of Science:
- Pediatric respiratory medicine
- Sleep medicine
- Medical device technology
Background:
- Limited data exists on ventilatory settings for children using CPAP or NIV.
- A French national survey identified 1447 children treated with long-term CPAP/NIV in 2019.
Purpose of the Study:
- To report on CPAP/NIV settings used in a pediatric population.
- To analyze these settings based on patient age and underlying disorders.
Main Methods:
- Analysis of CPAP/NIV settings from a French national survey of 1447 children.
- Comparison of settings across five age groups and six disease categories.
Main Results:
- CPAP pressure positively correlated with age; adherence decreased with age.
- NIV inspiratory positive airway pressure (IPAP) increased with age, while respiratory rate and adherence decreased.
- Ventilatory settings showed minimal variation across different pediatric disease categories.
Conclusions:
- Pediatric CPAP pressure and NIV IPAP increase with patient age.
- Ventilatory settings are largely consistent across various pediatric diseases.
- Individual patient assessment is crucial for optimal CPAP/NIV therapy adaptation.
Background:
A French national survey showed that 1447 children were treated with long-term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in 2019. Data about the ventilatory settings for children are scarce. The aim of the study was to report the CPAP/NIV settings from the survey according to the patients' age and disorders.
Methods:
CPAP and NIV settings were compared between 5 age groups (<1, 1-5, 6-11, 12-17 and ≥ 18 years), and 6 disease categories (upper airway disorders; neuromuscular disease, NMD; disorder of the central nervous system; cardiorespiratory disorder; congenital bone disease, CBD; and other).
Results:
Age correlated positively with constant CPAP pressure (r = 0.364, p < 0.0001), and negatively with CPAP adherence (r = -0.173, p < 0.0001). Mean age at CPAP initiation, CPAP pressures and adherence did not differ between disorders. Regarding NIV, mean inspiratory positive airway pressure (IPAP) increased with age (r = 0.152, p = 0.0001), whereas respiratory rate (RR; r = -0.593, p < 0.0001) and adherence to NIV decreased with age (r = -0.154, p = 0.0002). NIV settings were quite similar between disease categories, with the CBD group having the highest IPAP, and NMD group having the lowest expiratory positive airway pressure and RR. Adherence tended to be higher with NIV than CPAP.
Conclusions:
CPAP pressure and IPAP increase with age, while settings seem quite similar between diseases. Even if our study provides some information about CPAP/NIV settings, they should always be individually adapted according to the severity of the disease.
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