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Auditory pathway abnormalities in Parkinson's disease
Rafaela Valiengo de Souza1, Liliane Aparecida Fagundes Silva1, Carla Gentile Matas1
1Universidade de São Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, São Paulo SP, Brazil.
Arquivos De Neuro-Psiquiatria
|February 6, 2025
Summary
Parkinson's disease (PD) patients show higher hearing thresholds at high frequencies. While auditory brainstem responses (ABR) were similar, cortical auditory evoked potentials (CAEP) revealed reduced amplitudes, indicating impaired auditory processing in PD.
Area of Science:
- Neuroscience
- Audiology
- Clinical Neurology
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder impacting the central nervous system due to dopamine deficiency.
- Auditory evoked potentials (AEP) offer a method to assess central nervous system function.
Purpose of the Study:
- To evaluate audiometric responses and auditory evoked potentials (AEP) in individuals with Parkinson's disease.
- Specifically characterize auditory brainstem response (ABR) and cortical auditory evoked potentials (CAEP) in PD patients.
Main Methods:
- Compared 16 PD patients with 16 age- and sex-matched controls.
- Utilized pure tone audiometry, ABR with click stimuli, and CAEP with tone burst and speech stimuli.
- Employed repeated measures ANOVA for statistical analysis.
Main Results:
- PD patients exhibited significantly higher hearing thresholds at 6 and 8 kHz.
- No significant differences were found in auditory brainstem response (ABR) between groups.
- Cortical auditory evoked potentials (CAEP) showed reduced amplitudes in PD patients, despite similar latencies.
Conclusions:
- Parkinson's disease is associated with elevated hearing thresholds in higher frequencies.
- While brainstem auditory processing appears unaffected, reduced CAEP amplitudes suggest deficits in cortical auditory processing, encompassing both automatic and attentional aspects, in PD patients.
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