Related Experiment Video
Updated: May 29, 2025
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Advancements and future directions in chronic rhinosinusitis: understanding inflammatory mechanisms (2000-2023)
Sheng Long1, Huan Wang1, Wanpeng Li1
1Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai, 200031, China.
Objective:
To characterize research on inflammation in CRS over the past 23 years, and analyze trends in hotspots, and collaboration networks.
Methods:
We conducted a methodological, objective, and extensive analysis of inflammation in CRS to track research trends and hotspots. Original research literature published between 2000 and 2023 was obtained from The Web of Science Core Collection (WoSCC) database. Data on country/region, institution, author, journal, keywords, and references were extracted using VOSviewer and CiteSpace for analysis.
Results:
The number of publications on inflammation in CRS has significantly increased over the past 23 years. The United States has been the most prolific contributor in terms of publications and collaborations. The top 10 high-frequency keywords were "chronic rhinosinusitis," "nasal polyps," "asthma," "inflammation," "sinusitis," "rhinosinusitis," "eosinophils," "nasal polyposis," "chronic rhinosinusitis with nasal polyps," and "allergic rhinitis." The timeline view revealed changes in keywords over time, with endotype and biologics emerging as recent hotspots.
Conclusions:
Substantial improvement has been made in the study of inflammation in CRS. The United States leads with the most published articles, productive institutions, and influential journals. Strengthening collaborations between institutions and countries is recommended. The current focus is primarily on immunotherapy, and inflammation in CRS is likely to continue being a prominent topic.
More Related Videos
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:17Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:23Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:24Cystic Fibrosis: Management
Sinus disease and chronic...