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Updated: May 29, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth

Kyoko Watanabe1, Reina Ogata1, Kenta Kajiwara2

  • 1Department of Pediatrics, NHO Kokura Medical Center, Kitakyushu, Japan.

Scientific Reports
|February 6, 2025
PubMed

Insights

Very-low-birth-weight infants (VLBWIs) show varied growth and development. Early developmental quotient (DQ) at age 3 predicts later outcomes better than growth metrics up to age 6.

Area of Science:

  • Neonatalogy
  • Developmental Pediatrics
  • Growth Monitoring

Background:

  • Very-low-birth-weight infants (VLBWIs) face significant risks for neurodevelopmental issues.
  • Understanding the long-term developmental trajectories of VLBWIs is crucial.

Purpose of the Study:

  • To investigate the association between developmental quotient (DQ) and growth profiles in VLBWIs up to age 6.
  • To determine if early DQ or growth predicts later neurodevelopmental outcomes.

Main Methods:

  • Retrospective cohort study of VLBWIs from two medical centers (n=133).
  • Analysis of growth parameters (weight, height) and DQ at ages 3 and 6 years.
  • Correlation and clustering analyses to identify predictive factors.

Main Results:

  • DQ at age 6 correlated with DQ at age 3.
  • VLBWIs with higher DQ (≥85) at age 6 had better weight and height at age 3.
  • DQ at age 3 was a stronger predictor of DQ at age 6 than growth profiles post-age 3.
  • Comparative analysis revealed dissociation between DQ and growth post-age 3.

Conclusions:

  • VLBWIs exhibit diverse growth and developmental patterns over the first 6 years.
  • Early developmental assessments (DQ at age 3) are more predictive of later neurodevelopmental status than growth parameters in VLBWIs.
  • Growth and development trajectories diverge in VLBWIs after age 3.

Keywords:
AgeCorrelationDevelopmentDivergenceGrowthVery-low-birth-weight infants (VLBWIs)

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