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Updated: May 29, 2025

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity
Published on: December 31, 2015
Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer
Lanning Bai1, Xueqian Qian2, Hui Zhang2
1School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, Shandong, 261053, P. R. China.
Background:
Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall 5-year survival rate ranging from 30 to 50%. Plectin (PLEC), a 500 kDa scaffolding protein, has gained prominence in recent years due to its pivotal role in various cellular biological functions such as cell morphology, migration and adhesion, while the accurate role of PLEC in OC remains elusive.
Results:
In this study, our findings demonstrate that PLEC exerts a positive influence on the progression of OC, encompassing cellular proliferation, migration, invasion, and adhesion both in vitro and in vivo.
Conclusions:
The results providing new insights for the diagnosis and treatment in OC.
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