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Unilateral ureteric ligation in diabetic rats: a pathologic and morphometric study
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
|January 1, 1985
Summary
Unilateral ureteral ligation significantly impacts the contralateral kidney, especially in diabetic rats. Diabetic rats showed greater left kidney size and more glomerular damage after ligation compared to controls.
Area of Science:
- Nephrology
- Diabetology
- Surgical Pathology
Background:
- Unilateral ureteral ligation (UUL) is a surgical procedure that can lead to compensatory hypertrophy in the contralateral kidney.
- Diabetes mellitus is known to affect kidney morphology and function, potentially altering the response to UUL.
Purpose of the Study:
- To investigate the combined effects of streptozotocin-induced diabetes and UUL on the contralateral kidney's morphology and pathology.
- To compare the compensatory response in diabetic versus non-diabetic rats subjected to UUL.
Main Methods:
- Rats were induced with diabetes using streptozotocin.
- Unilateral ureteral ligation was performed on the right ureter in both diabetic and control groups.
- Morphological and pathological changes in the contralateral (left) kidney were assessed, including weight, volume, and tissue specific gravity.
Main Results:
- Diabetic rats undergoing UUL exhibited significantly greater left kidney weight and volume compared to control rats and rats with only ureteral ligation.
- A lower tissue specific gravity was observed in the contralateral kidney of diabetic rats post-ligation.
- The percentage of affected glomeruli in the contralateral kidney was significantly higher in the diabetic group that underwent UUL.
Conclusions:
- Diabetes exacerbates the compensatory hypertrophy and pathological changes in the contralateral kidney following UUL.
- Diabetic kidneys are more susceptible to damage and altered morphology when subjected to the stress of contralateral ureteral obstruction.