Environmental stimuli-responsive hydrogels in endodontics: Advances and perspectives

Stimuli-responsive hydrogels are smart and functional materials that respond to various environmental stimuli, including temperature, light, magnetic field, pH, redox, enzymes and glucose. This responsiveness allows for the controlled release of therapeutic agents encapsulated within the hydrogels, enhancing treatment precision, improving therapeutic outcomes and minimizing side effects. Such hydrogels show great potential in root canal disinfection, management of dental pulp inflammation and pulp regeneration, making them promising candidates for more personalized and effective endodontic treatments. This article provides an overview of the latest advancements in the design and application of stimuli-responsive hydrogels in endodontics, emphasizing their potential to revolutionize endodontic treatments. It also addresses current challenges and explores future directions in the field, aiming to inspire and motivate researchers to further engage in or intensify their efforts within this promising area of research.