Related Experiment Video

Updated: May 29, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

3.8K

The gut microbiota and its role in the development of cardiovascular disease

Carlos Escobar1, Xavier Aldeguer2, David Vivas3,4

  • 1Cardiology Department, University Hospital La Paz, Madrid, Spain.

Expert Review of Cardiovascular Therapy
|February 7, 2025
PubMed
Abstract

Insights

Gut microbiota dysbiosis contributes to cardiovascular disease risk through altered metabolites and gut permeability. Interventions like diet modification and fecal microbiota transplantation show promise in restoring balance and reducing disease risk.

Area of Science:

  • Microbiology
  • Cardiology
  • Metabolomics

Background:

  • Cardiovascular diseases (CVD) involve complex genetic and environmental factors, with residual risk remaining even after managing traditional risk factors.
  • The gut microbiota's role in CVD pathophysiology is an emerging area of research.

Purpose of the Study:

  • To review the potential role of gut microbiota in cardiovascular disease development.
  • To explore the gut microbiota as a potential therapeutic target for CVD.

Main Methods:

  • A systematic literature search was conducted on PubMed (MEDLINE) up to October 30, 2024.
  • Search terms included "Gut microbiota", "Dysbiosis", "Cardiovascular", "TMAO", "bile acids", and "short-chain fatty acids".

Main Results:

  • Dysbiosis is characterized by reduced microbial diversity, altered metabolite production (e.g., trimethylamine N-oxide, short-chain fatty acids), increased gut permeability, and changes in bile acid metabolism.
  • These alterations contribute to inflammation, oxidative stress, endothelial dysfunction, and the onset of conditions like obesity, hypertension, diabetes, atherosclerosis, and heart failure.

Conclusions:

  • Restoring gut microbiota balance through dietary changes, probiotics, prebiotics, or fecal microbiota transplantation may positively impact CVD risk factors and outcomes.
  • Targeting the gut microbiota represents a promising therapeutic strategy for cardiovascular disease.
Keywords:
Bile acidsTMAOcardiovasculardysbiosisgut microbiotalipopolysaccharideshort-chain fatty acids

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

13.9K

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
375
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
234