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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Blood and Nerve Supply to the Bones01:29

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Updated: May 29, 2025

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
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Patients in pain.

Stefan Timmermans1, Tanya Stivers1, Keith Cox1

  • 1University of California, Los Angeles.

Communication & Medicine
|February 7, 2025
PubMed
Summary
This summary is machine-generated.

Physicians can reduce patient resistance to non-opioid pain treatments by presenting them as new, specific, and personalized solutions. This communication strategy is key for managing chronic pain and addressing the opioid crisis.

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Area of Science:

  • Medical Communication
  • Pain Management
  • Public Health

Background:

  • Pain is a primary reason for primary care physician visits.
  • Overprescription of opioids for chronic pain is a significant public health issue and risk factor for addiction.

Purpose of the Study:

  • To investigate how primary care physicians communicate recommendations for non-opioid alternatives to opioid treatments.
  • To examine the link between physician communication strategies and patient resistance to these alternatives for chronic musculoskeletal pain.

Main Methods:

  • Analysis of 35 video-recorded primary care visits for moderate to severe chronic musculoskeletal pain.
  • Utilized abductive analysis, conversation analysis, and descriptive statistics.

Main Results:

  • Physicians encountered less patient resistance when framing non-opioid recommendations as novel.
  • Presenting treatments as concrete and tailored to the patient's specific pain problem also reduced resistance.

Conclusions:

  • Effective communication strategies can improve patient acceptance of non-opioid pain treatments.
  • Physician communication plays a crucial role in overcoming patient resistance and potentially mitigating the opioid crisis.