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Related Concept Videos

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

5.9K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.7K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.7K
Thermal and Photochemical Electrocyclic Reactions: Overview01:26

Thermal and Photochemical Electrocyclic Reactions: Overview

2.3K
Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
2.3K
Five-Membered Heterocyclic Aromatic Compounds: Overview01:13

Five-Membered Heterocyclic Aromatic Compounds: Overview

3.7K
Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom,...
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Related Experiment Video

Updated: May 29, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

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Exploring Thiophene Derivatives: Synthesis Strategies and Biological Significance.

Isha Mishra1, Vikram Sharma1, Nitin Kumar2

  • 1Department of Pharmacy, Galgotias College of Pharmacy, Greater Noida, Uttar Pradesh 201310, India.

Medicinal Chemistry (Shariqah (United Arab Emirates))
|February 7, 2025
PubMed
Summary

Thiophene derivatives offer versatile synthesis routes and diverse biological activities, including anti-cancer and anti-inflammatory effects. This review highlights their potential for developing novel pharmaceutical treatments.

Keywords:
5-membered ringHeterocyclic compoundsbiological potentialstructure-activity relationship.synthesisthiophene

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Last Updated: May 29, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Thiophene derivatives are crucial sulfur-containing heterocycles with significant pharmacological properties.
  • Their structural similarity to natural and synthetic compounds makes them valuable in drug discovery.
  • This study focuses on the synthesis and biological functions of thiophene derivatives.

Purpose of the Study:

  • To comprehensively review synthetic pathways for thiophene derivatives.
  • To investigate the diverse biological functions of these compounds.
  • To provide insights for rational drug design and development.

Main Methods:

  • Literature review of synthesis methods, including traditional (Gewald reaction) and modern techniques (microwave-assisted, green synthesis).
  • Compilation of in vitro and in vivo studies on 50 distinct thiophene derivatives.
  • Analysis of structure-activity relationships to identify key structural elements for biological activity.

Main Results:

  • Diverse synthetic methodologies, both conventional and contemporary, are available for thiophene derivatives.
  • Thiophene derivatives exhibit a broad spectrum of biological activities, including anti-cancer, anti-inflammatory, antiprotozoal, antibacterial, antioxidant, and antiviral functions.
  • Structure-activity relationship studies have elucidated key structural features essential for biological efficacy.

Conclusions:

  • Thiophene derivatives are promising scaffolds in medicinal and pharmaceutical chemistry due to their synthetic flexibility and broad biological potential.
  • Understanding synthesis and biological actions aids in designing novel therapeutics.
  • Further exploration and optimization of thiophene derivatives hold significant promise for future drug development initiatives.