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Research Progress on the Material Basis of Traditional Chinese Medicines Based on Chemical Biology Methods
Xinyue Bai1,2, Huimin Lin1,2, Ziqi Yang1,2
1Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong-Macao In-Depth Cooperation Zone in Hengqin, China.
Abstract:
The chemical biology method is a cutting-edge technology that utilizes chemical research methods and ideas to study life and biomedicine at the molecular level. Recently, it has gradually been applied to screening chemical markers in traditional Chinese medicines. This article reviews the principles and applications of common chemical biology methods, including cell membrane chromatography, affinity ultrafiltration, magnetic bead enrichment, capillary electrophoresis, molecular exclusion chromatography, immobilized fusion target affinity chromatography, etc., in traditional Chinese medicines research. Applying chemical biology methods to screen chemical markers in traditional Chinese medicines has the advantages of simple and fast operation, strong specificity of results, good reproducibility, and high sensitivity, which can achieve high-throughput screening.
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