Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Electrical Synapses

Electrical Synapses

Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...

The Role of Ion Channels in Neuronal Computation

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....

Neuronal Communication

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.

iScience·2025

Same author

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex.

Neuron·2025

Same author

A dendritic substrate for temporal diversity of cortical inhibition.

bioRxiv : the preprint server for biology·2024

Same author

Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions.

Cell reports·2024

Same author

Gamma oscillation plasticity is mediated via parvalbumin interneurons.

Science advances·2024

Same author

A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.

PLoS computational biology·2023

Search research articles

Related Experiment Video

Updated: May 5, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease.

Yann Zerlaut¹, Alexandra Tzilivaki^2,3,4

¹Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France.

Frontiers in Cellular Neuroscience

|February 7, 2025

Summary

Cortical inhibition, mediated by specific interneurons, goes beyond stability control to actively modulate neural network computations. Disruptions in these interneurons can impair flexible cortical processing and contribute to disorders.

Keywords:

NDNF interneurons cortex cortical computation inhibition interneuron vasoactive intestinal peptide

More Related Videos

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Related Experiment Videos

Last Updated: May 5, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Cortical inhibition traditionally viewed for network stability and refining representations.
Key challenge in neurophysiology: understanding the full scope of inhibition's roles.

Purpose of the Study:

Propose that specific interneurons modulate neural network computational properties.
Review evidence supporting this complementary role of interneurons.
Explore implications of interneuron dysfunction for cortical flexibility and disorders.

Main Methods:

Review of experimental and theoretical evidence.
Focus on rodent sensory cortices.
Exploration of computational modeling concepts.

Main Results:

Evidence supports interneurons actively modulating computational modes.
Specific interneuron subtypes contribute to diverse computational functions.
Dysfunction linked to impaired network flexibility.

Conclusions:

Interneurons play a crucial role in computational flexibility beyond stability.
Dysfunctional interneurons may underlie neurodevelopmental and psychiatric disorders.
Further research needed to elucidate specific interneuron computations.