Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease

Understanding cortical inhibition and its diverse roles remains a key challenge in neurophysiological research. Traditionally, inhibition has been recognized for controlling the stability and rhythmicity of network dynamics, or refining the spatiotemporal properties of cortical representations. In this perspective, we propose that specific types of interneurons may play a complementary role, by modulating the computational properties of neural networks. We review experimental and theoretical evidence, mainly from rodent sensory cortices, that supports this view. Additionally, we explore how dysfunctions in these interneurons may disrupt the network's ability to switch between computational modes, impacting the flexibility of cortical processing and potentially contributing to various neurodevelopmental and psychiatric disorders.