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Updated: Dec 29, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Eight rules for the haemodynamic management of traumatic brain-injured patients
Simone Di Filippo1, Antonio Messina1, Paolo Pelosi1
1From the Department of Biotechnology and Sciences of Life, Anesthesia and Intensive Care, ASST Sette Laghi, University of Insubria, Varese (SDF), IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, Rozzano (AM), Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan (AM), IRCCS Ospedale Policlinico San Martino (PP, CR) and Department of Surgical Sciences and Integrated Diagnostics, DISC, University of Genoa, Genoa, Italy (PP, CR).
Abstract:
Traumatic brain injury (TBI), a leading cause of death and poor neurological outcomes in trauma patients, is a primary cause of severe disability among survivors and a major public health burden globally. Optimal haemodynamic management is a keystone of care in avoiding secondary brain injury, and contributes to minimising mortality and morbidity. Although some important progress has been achieved, a paucity of high-quality recommendations still exists. The purpose of this article is to review the current knowledge on TBI-associated haemodynamic tenets, in order to summarise the most important aspects of this heterogeneous and complex field.
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