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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

464
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

329
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Intralymphatic Immunotherapy and Vaccination in Mice
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Incorporating Immunotherapy with Radiotherapy for Lymphomas.

Paolo Strati1, Michael T Spiotto2

  • 1Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Lymphatics
|February 7, 2025
PubMed
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Immunotherapy offers new lymphoma treatment options, potentially synergizing with radiotherapy. However, combining these treatments requires further research to optimize efficacy and manage immune responses for better patient outcomes.

Keywords:
immunotherapylymphomaradiotherapy

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Area of Science:

  • Oncology
  • Immunology
  • Radiation Oncology

Background:

  • Lymphoma treatment has historically relied on radiotherapy and chemotherapy for nearly a century.
  • Recent advancements have introduced immunotherapy as a novel therapeutic strategy for lymphoma.
  • Understanding the interplay between immunotherapy and conventional treatments is crucial for improving patient care.

Purpose of the Study:

  • To review the current role of immunotherapy in lymphoma treatment.
  • To assess the feasibility of combining immunotherapies with conventional lymphoma therapies, particularly radiotherapy.
  • To explore the potential synergistic or antagonistic effects of combined treatment modalities.

Main Methods:

  • Review of existing literature on immunotherapy agents including checkpoint inhibitors (PD-1/PD-L1, CTLA-4, CD47), bi-specific antibodies, and CD19 CAR-T cell therapy.
  • Analysis of studies examining the combination of immunotherapy with radiotherapy and chemotherapy in lymphoma.
  • Extrapolation of findings from other disease sites to inform lymphoma treatment strategies.

Main Results:

  • Immunotherapy agents like checkpoint inhibitors, bi-specific antibodies, and CAR-T cells are increasingly used in non-Hodgkin's lymphomas.
  • Combining immunotherapy with radiotherapy/chemotherapy may yield synergistic anti-tumor immune responses or lead to immune dysfunction, reducing efficacy.
  • Modern radiotherapy techniques and limited radiation fields may preserve immunotherapy efficacy.

Conclusions:

  • There is a significant need to elucidate the precise role of immunotherapy, both as a standalone treatment and in combination with conventional therapies for lymphoma.
  • Further research is required to optimize combination strategies, balancing potential benefits against risks of immune modulation.
  • Integrating immunotherapy into lymphoma treatment paradigms holds promise but necessitates careful investigation into its interactions with radiotherapy and chemotherapy.