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Bringing intranasal drug delivery for malignancies in the brain to market

Thomas C Chen1,2,3, Clovis O da Fonseca4, Axel H Schönthal5

  • 1Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.

Expert Opinion on Drug Delivery
|February 7, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Blood–brain barrierNEO100brain cancergliomameningiomanose-to-brain pathwayperillyl alcoholtemozolomide

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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