Related Experiment Video

Updated: May 29, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Importance of STAT3 signaling in preeclampsia (Review)

Daniela Marzioni1, Federica Piani2, Nicoletta Di Simone3

  • 1Department of Experimental and Clinical Medicine, Polytechnic University of Marche, I‑60126 Ancona, Italy.

International Journal of Molecular Medicine
|February 7, 2025
PubMed

Insights

This review explores Signal Transducer and Activator of Transcription 3 (STAT3) signaling in preeclampsia (PE). It identifies compounds and cellular modulators targeting STAT3 for improved pregnancy outcomes.

Area of Science:

  • Reproductive biology
  • Molecular signaling
  • Pathophysiology of pregnancy

Background:

  • Placentation is crucial for normal fetal development.
  • Preeclampsia (PE) involves oxidative stress and inflammation during pregnancy.
  • Signal Transducer and Activator of Transcription 3 (STAT3) signaling regulates key cellular processes.

Purpose of the Study:

  • To analyze the role of STAT3 signaling in preeclampsia.
  • To discuss compounds modulating STAT3 in PE.
  • To identify therapeutic targets for preeclampsia.

Main Methods:

  • Literature review of STAT3 signaling in PE.
  • Analysis of in vivo and in vitro studies.
  • Summary of cellular modulators of STAT3.

Main Results:

  • STAT3 signaling is implicated in preeclampsia pathogenesis.
  • Various natural and synthetic compounds influence STAT3 activity.
  • Cellular modulators offer potential therapeutic avenues.

Conclusions:

  • STAT3 signaling is a critical target for preeclampsia treatment.
  • Modulating STAT3 offers promise for improving pregnancy outcomes.
  • Further research into STAT3 pathways can lead to novel therapies.

Keywords:
STAT3compoundhypoxiainflammationpreeclampsia

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