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Eruptive Process in Children with Osteogenesis Imperfecta.

Clara Sandibel Garcete Delvalle1, M Joaquín De Nova García2, María Rosa Mourelle Martínez2

  • 1Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain. cgarcete@ucm.es.

Calcified Tissue International
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PubMed
Summary
This summary is machine-generated.

Bisphosphonates (BPs) used for Osteogenesis Imperfecta (OI) in children may delay tooth development, root resorption, and permanent molar eruption. These effects, though often subtle, highlight the importance of monitoring dental health in OI patients undergoing BP treatment.

Keywords:
Alveolar eruptionBisphosphonatesDental developmentDental exfoliationOsteogenesis ImperfectaPanoramic radiographPermanent dentitionPrimary dentitionRoot resorption

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Area of Science:

  • Pediatric Dentistry
  • Orthodontics
  • Genetics and Hereditary Diseases

Background:

  • Osteogenesis Imperfecta (OI) is a genetic disorder causing bone fragility.
  • Bisphosphonates (BPs) are used to increase bone density in children with OI.
  • BPs are antiresorptive agents that can impact physiological processes involving osteoclasts, such as tooth eruption.

Purpose of the Study:

  • To investigate the effects of bisphosphonate (BP) treatment on the eruptive process in children with Osteogenesis Imperfecta (OI).
  • To compare dental development, primary tooth resorption, and first permanent molar eruption in children with OI on BPs versus a control group.
  • To analyze the correlation between cumulative BP dosage and potential delays in dental development.

Main Methods:

  • Retrospective analysis of panoramic radiographs from 34 children with OI on BPs and 367 healthy children.
  • Utilized the Demirjian method for permanent tooth development assessment and the Haavikko method for primary tooth root resorption.
  • Measured alveolar eruption of the first permanent molar and calculated cumulative BP dosage.

Main Results:

  • Children with OI on BPs exhibited delayed dental development (0.95 points) and primary tooth exfoliation (1.31–1.66 years).
  • A significant delay in primary tooth root resorption was observed (11.8% overall, varying by tooth type).
  • Delayed alveolar eruption of the first permanent molar (0.31 years) was noted, with greater delays in those with higher cumulative BP doses (>2000).

Conclusions:

  • Bisphosphonate therapy in children with OI can lead to clinically subtle but statistically significant delays in dental development and eruption.
  • Primary tooth root resorption is also affected by BP treatment, indicating a broader impact on the dentition.
  • Monitoring dental development and eruption is crucial for children with OI receiving bisphosphonate therapy, especially considering cumulative dosage.