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Therapeutic implications of baricitinib in mouse model of vitiligo
Harjot Kaur1, Kanika Thakur1, Davinder Parsad2
1Department of Zoology, Panjab University, Chandigarh, 160014, India.
Introduction:
Vitiligo, an autoimmune disorder marked by skin depigmentation, is closely linked to immune dysregulation, including T cell infiltration and pro-inflammatory cytokines. This study explores the potential of baricitinib, a JAK-STAT inhibitor, in promoting repigmentation in vitiligo lesions by modulating immune responses.
Methods:
Using a mouse model of vitiligo induced by hydroquinone, we assessed the effects of baricitinib treatment on lesion repigmentation, CD8 + T cell infiltration, T cell populations, and serum TNF-α levels. Immunostaining, flow cytometry, and ELISA were used to analyse these parameters.
Results:
Baricitinib treatment significantly reduced CD8 + T cell infiltration in the skin, lowered serum TNF-α levels, and decreased both CD4 + and CD8 + T cell populations in the blood. Remarkably, these immune modulations correlated with notable repigmentation of the lesions.
Conclusion:
Baricitinib effectively reduces inflammation and T cell infiltration, suggesting it as a promising therapeutic for vitiligo. These findings highlight its potential to modulate immune responses and restore skin pigmentation in vitiligo patients.
