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Updated: May 29, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Four New Cassane Diterpenoids From the Seeds of Caesalpinia Mimosoides
Yu-Xin Ma1, Xiao-Chen Pu1, Rong-Gang Xi2
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Abstract:
Four new cassane derivatives (1-4), along with five known compounds (5-9) were isolated from the seeds of Caesalpinia mimosoides. Their gross structures were elucidated by means of comprehensive spectroscopic analysis (ultraviolet, nuclear magnetic resonance, and high-resolution electrospray ionization mass spectrometry) as well as electronic circular dichroism calculations. Compounds 1-3 possessing norcassane-type skeleton were observed, which was a rare structural type in the Caesalpinia genus. The results of biological activity evaluation showed that compounds tested could inhibit the production of nitric oxide in lipopolysaccharide-induced RAW 264.7 cells, especially compound 8 exhibited excellent inhibitory activity, implying that these compounds may be potential anti-inflammatory candidates.
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