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Related Experiment Videos

Tricyclic response in obsessive compulsive disorder.

T R Insel, E A Mueller, J C Gillin

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1985
    PubMed
    Summary

    Clomipramine effectively treats obsessive-compulsive disorder (OCD) and may be more effective than desipramine for OCD patients. This antidepressant

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    Area of Science:

    • Psychiatry and Neurobiology
    • Pharmacology

    Background:

    • Obsessive-compulsive disorder (OCD) shares some biological markers with depression.
    • Previous research indicates therapeutic responses to clomipramine in OCD patients.

    Purpose of the Study:

    • To evaluate the efficacy of clomipramine in treating OCD.
    • To differentiate the therapeutic response of OCD patients from that of depressed patients.

    Main Methods:

    • Five double-blind studies were reviewed.
    • Comparison of biological markers between OCD patients and depressed patients.
    • Assessment of patient response to clomipramine and desipramine.

    Main Results:

    • Clomipramine demonstrated therapeutic responses in five double-blind studies for OCD.

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  • OCD biological alterations resemble those in depression for DST, sleep physiology, and clonidine response.
  • Clomipramine's antiobsessional effect is independent of baseline depression severity.
  • Preliminary findings suggest OCD patients respond to clomipramine, unlike desipramine, in contrast to depressives.

    • Conclusions:

    • Clomipramine is an effective treatment for obsessive-compulsive disorder.
    • The therapeutic mechanism of clomipramine in OCD may differ from its action in depression.
    • Further research is warranted to explore differential treatment responses in psychiatric disorders.