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Bioresorbable Suture Anchor Clips for Soft Tissue Wound Repair.

Alexander J Bahnick1, David Ruppert2, Gabriella A Krisanic1

  • 1Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Biomacromolecules
|February 7, 2025
PubMed
Summary
This summary is machine-generated.

Novel bioresorbable anchor clips were developed for mesh sutures, addressing infection risks associated with traditional knots. These degradable devices offer a promising solution for secure soft tissue fixation in wound closure.

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • 3D Printing in Medicine

Background:

  • Mesh sutures are used for high-tension wounds, but knots pose infection and irritation risks.
  • A need exists for degradable, knotless anchoring systems to improve mesh suture safety and efficacy.
  • Current methods lack ideal solutions for secure and biocompatible soft tissue fixation.

Purpose of the Study:

  • To develop and evaluate novel, bioresorbable anchor clips for securing mesh sutures.
  • To compare 3D printed and injection-molded anchor clips for mechanical properties and biocompatibility.
  • To assess the clinical translation potential of these advanced wound closure devices.

Main Methods:

  • Fabrication of anchor clips using continuous liquid interface production (CLIP) 3D printing with poly(propylene fumarate-co-propylene succinate) (PPFPS).
  • Thiol-ene cross-linking to create fully degradable PPFPS thermoset devices with tunable mechanical properties.
  • Fabrication of comparative anchor clips using injection molding with poly(l-lactide-co-glycolide) (PLGA).
  • Benchtop testing in an abdominal wall reconstruction model and *in vivo* biocompatibility assessment in a porcine model.

Main Results:

  • Both PLGA and PPFPS anchor clips demonstrated satisfactory *in vivo* biocompatibility in a porcine abdominal implantation model.
  • PLGA anchor clips exhibited mechanical performance comparable to existing soft tissue fixation techniques.
  • 3D printed PPFPS devices offered tunable mechanical properties, indicating versatility in application.

Conclusions:

  • Novel bioresorbable anchor clips were successfully developed using 3D printing and traditional molding techniques.
  • These anchor clips present a viable, safer alternative to traditional mesh suture knots, reducing infection risks.
  • The developed anchor clips show significant potential for clinical translation in soft tissue fixation and wound management.