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Platelet Additive Solutions and Pathogen Reduction Impact on Transfusion Safety, Patient Management and Platelet
Georges Andreu1, Karim Boudjedir1, Nicolas Meyer2
1French National Agency for Medicines and Health Products Safety (ANSM), Saint Denis, France.
Transfusion Medicine Reviews
|February 7, 2025
Summary
Platelet additive solutions (PAS) and pathogen reduction technology (PR) significantly lowered adverse transfusion reactions (ATRs) compared to plasma. Pathogen reduction technology demonstrated a 95% reduction in bacterial transmission, improving blood safety.
Area of Science:
- Transfusion Medicine
- Hematology
- Public Health
Background:
- Leukoreduction of platelet concentrates (PCs) has been standard in France since 1998.
- Platelet additive solutions (PAS) and pathogen reduction technology (PR) have been increasingly implemented.
- The use of buffy-coat-derived PCs (BCPCs) rose from 23% to 70% between 2007 and 2021.
Purpose of the Study:
- To evaluate the impact of PAS and PR on adverse transfusion reactions (ATRs).
- To assess changes in patient management and blood transfusion organization.
- To compare ATR incidence between apheresis-derived PCs (APCs) and BCPCs.
Main Methods:
- Retrospective analysis of transfusion data from 2007 to 2021 in France.
- Comparison of ATR incidence across different PC processing methods (plasma, PAS, PR).
- Analysis of ATR types, including bacterial transmission and alloimmunization.
Main Results:
- PAS- and PR-PCs showed lower overall ATR incidence than plasma-PCs (PL).
- PR-PCs significantly reduced transfusion-transmitted bacterial infections (TTBI) by 95%.
- APCs had higher ATR rates for allergy, TTBI, and alloimmunization compared to BCPCs.
Conclusions:
- PAS and PR technologies have improved blood safety by reducing ATRs.
- Pathogen reduction technology is highly effective in preventing bacterial transmission.
- While PR-PCs have lower platelet content, they contribute to a decrease in overall ATR incidence per PC.
Keywords:
HemovigilancePlatelet additive solutionsPlatelet pathogen reductionPlatelet transfusionTransfusion-transmitted infectionsMore Related Videos
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