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Pre-birth stem cell education: A gift from mother's bugs
1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Cell Stem Cell
|February 7, 2025
Summary
Modifying the maternal gut microbiome during pregnancy influences offspring neural and intestinal stem cells. These changes, mediated by the mTOR pathway, have lasting functional impacts on development.
Area of Science:
- Microbiology
- Developmental Biology
- Neuroscience
Background:
- The maternal gut microbiota composition changes significantly during pregnancy.
- The maternal microbiome is crucial for offspring development.
Purpose of the Study:
- To investigate how maternal gut microbiome modifications during pregnancy impact offspring stem cell development.
- To explore the underlying molecular pathways involved in these effects.
Main Methods:
- Maternal gut microbiome manipulation during pregnancy.
- Analysis of offspring neural and intestinal stem cells.
- Investigation of the mechanistic target of rapamycin (mTOR) pathway.
Main Results:
- Maternal microbiome alterations during pregnancy shape offspring neural stem cells.
- Maternal microbiome alterations during pregnancy shape offspring intestinal stem cells.
- The mechanistic target of rapamycin (mTOR) pathway is involved in mediating these effects.
Conclusions:
- Maternal gut microbiome composition during pregnancy has long-lasting effects on offspring stem cell function.
- Targeting the maternal microbiome could be a strategy to influence offspring development via the mTOR pathway.
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