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Updated: May 29, 2025

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Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes.

Xiaoyan Yang1, Xiaoyu Zhou2, Wenhao Hu3

  • 1State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

Nature Communications
|February 7, 2025
PubMed
Summary

This study introduces a new catalytic method using alpha-halo Rh-carbenes for multi-functionalization reactions. It enables the efficient synthesis of chiral compounds with high yield and enantioselectivity.

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