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Critical appraisal of methodological issues in a study on botulinum toxin for 'outlet-type' constipation

Ugo Grossi1,2

  • 1Surgery Unit 2, Regional Hospital Treviso 'Cittadella della Salute', Piazzale Ospedale 1, 31100, Treviso, Italy. ugo.grossi@unipd.it.

International Journal of Colorectal Disease
|February 7, 2025
PubMed
Abstract

No abstract available in PubMed .

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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