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Related Experiment Video

Updated: May 29, 2025

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution.

Tianyuan Zhao^1,2, Qing Zhong^1,2, Zewen Sun^1,2

¹Department of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.

Stem Cell Research & Therapy

|February 7, 2025

Summary

Researchers discovered a unique stem cell population in mouse incisors and human tooth roots crucial for continuous tooth growth. This finding offers new avenues for dental tissue regeneration and repair strategies.

Keywords:

Dental pulp stem cells Evolution SFRP2 Single-cell transcriptomics Tissue growth

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Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor

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Last Updated: May 29, 2025

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

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Published on: July 8, 2021

Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment

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Published on: October 27, 2023

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor

Published on: May 1, 2014

Area of Science:

Dental Biology
Stem Cell Research
Comparative Genomics

Background:

Single-cell transcriptomics advances tooth biology research.
Mice are key models for human dental pulp studies, though incisors differ from human teeth.
Translating mouse dental findings to human disease requires further exploration.

Purpose of the Study:

To construct a comprehensive dental pulp cell landscape.
To identify similarities and species-specific differences between human and mouse dental pulp.
To understand the mechanisms underlying tooth growth.

Main Methods:

Utilized multiple single-cell transcriptomic datasets.
Compared cell populations between human and mouse dental pulp.
Investigated gene regulation and signaling pathways involved in stem cell identity.

Main Results:

Identified Sfrp2hi fibroblast progenitors exclusively in mouse incisors and developing human molar roots.
These cells are critical for sustaining continuous tissue growth.
Discovered Twist1 transcription factor regulates Sfrp2 expression and Wnt signaling for stem cell maintenance.

Conclusions:

Revealed a novel subset of dental mesenchymal stem cells essential for tooth growth.
This evolutionarily conserved cell subset offers insights for dental tissue regeneration.
Findings support translational approaches for dental repair.