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Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Ziyi Wang1,2, Chao Wu1,2, Dong Yin3,4

  • 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cardiovascular Diabetology
|February 7, 2025
PubMed

Insights

Diabetic cardiovascular diseases involve ferroptosis, a cell death pathway. Targeting ferroptosis offers new therapeutic strategies for heart complications in diabetes.

Area of Science:

  • Biomedical Science
  • Cardiology
  • Metabolic Diseases

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of death in diabetic patients.
  • Ferroptosis, a form of regulated cell death driven by iron and lipid peroxidation, is implicated in diabetic CVD pathogenesis.
  • Hyperglycemia in diabetes contributes to myocardial iron accumulation, altered lipid metabolism, and oxidative stress, increasing ferroptosis susceptibility.

Purpose of the Study:

  • To review the mechanisms of ferroptosis in the development of diabetic cardiovascular diseases.
  • To explore novel therapeutic strategies targeting ferroptosis pathways for diabetic heart conditions.

Main Methods:

  • Literature review of studies on ferroptosis and diabetic cardiovascular diseases.
  • Analysis of the role of iron, lipid metabolism, and oxidative stress in ferroptosis.
  • Examination of potential therapeutic interventions targeting ferroptosis.

Main Results:

  • Ferroptosis plays a significant role in the pathophysiology of diabetic cardiovascular complications.
  • Myocardial iron overload, lipid dysregulation, and oxidative stress are key factors promoting ferroptosis in diabetic hearts.
  • Targeting ferroptosis pathways presents promising therapeutic avenues for managing diabetic cardiovascular diseases.

Conclusions:

  • Ferroptosis is a critical mediator of cardiac injury in diabetes.
  • Understanding ferroptosis mechanisms can lead to the development of effective treatments for diabetic cardiovascular diseases.
  • Further research into ferroptosis-mediated cardiac damage is essential for advancing therapeutic options.

Keywords:
Cardiovascular diseasesDiabetesFerroptosisMechanismTherapeutic targets

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