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Updated: Aug 4, 2026

Engineering a Bilayered Hydrogel to Control ASC Differentiation
Published on: May 25, 2012
Controlled platelet-derived growth factor delivery by hyaluronic acid hydrogels with tunable crosslinking for
Xiaoyan Qin1, Hongxia Yuan1, Ming Zhang2
1College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Abstract:
Chronic wound healing is a complex process requiring sustained activity of growth factors across the whole healing process. Among these growth factors, platelet-derived growth factor (PDGF) plays a pivotal role. However, the short half-life of PDGF limits its therapeutic efficacy. This study introduces a hyaluronic acid-based hydrogel system loading with PDGF, MA-HA-Gelx/PDGF, designed for the controlled release of PDGF. By tuning the ratio of cross-linkers with different hydrolysis rates, the PDGF loaded hydrogel system ensures sustained release of bioactive PDGF. In vivo assays proved that, MA-HA-Gelx/PDGF could efficiently promote the proliferation and migration of fibroblasts. Furthermore, MA-HA-Gelx/PDGF could enhance neovascularization and accelerate the wound closure of a chronic wound bearing mouse model. This PDFG loaded hydrogel system offers a promising strategy for chronic wound treatment.
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