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Flucloxacillin-induced cholestatic liver damage.

F Bengtsson, C H Florén, I Hägerstrand

    Scandinavian Journal of Infectious Diseases
    |January 1, 1985
    PubMed
    Summary
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    Flucloxacillin can cause jaundice, a liver condition characterized by intrahepatic cholestasis. Symptoms resolved in two female patients after discontinuing the antibiotic medication.

    Area of Science:

    • Hepatology
    • Clinical Pharmacology

    Background:

    • Antibiotic-induced liver injury is a recognized adverse drug reaction.
    • Flucloxacillin is a commonly prescribed penicillinase-resistant penicillin antibiotic.

    Observation:

    • Two female patients, aged 75 and 68, presented with jaundice.
    • Jaundice developed 4 and 7 weeks after initiating flucloxacillin treatment.

    Findings:

    • Liver biopsies confirmed intrahepatic cholestasis in both patients.
    • Cessation of flucloxacillin led to normalization of liver tests.

    Implications:

    • This case series highlights flucloxacillin as a potential cause of drug-induced liver injury.
    • Physicians should consider flucloxacillin-induced cholestatic jaundice in patients presenting with these symptoms.

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