Toward a Universal Definition for Right Heart Failure: A Work in Progress

Broadly speaking, right heart failure (RHF) can be defined as a clinical syndrome with signs and symptoms of heart failure resulting from right ventricular dysfunction, as evidenced by abnormal structure or function. The heterogeneity of conditions associated with RHF combined with the challenges of characterizing the structural and functional relationships of the right ventricle make a singular definition of RHF elusive. We performed a concise scoping review of the literature that provides knowledge synthesis of RHF in different clinical populations, and extracted the recommended criteria to define the syndrome.

Searches were conducted to identify reviews, guidelines, consensus statements, systematic reviews, meta-analyses, and consensus statements concerning right heart or right ventricular failure in well-described adult human disease populations from the previous 10 years. After removal of case reports and duplicates, publications describing syndromes in the context of left-sided heart disease were also removed. Data extracted from selected manuscripts included the patient population and quantitative criteria to define RHF, categorized based on diagnostic modalities.

Of 9487 articles initially identified, 71 were selected for full text review. We found that the majority of the reviewed literature offered multifaceted diagnostic approaches, including clinical, echocardiographic, hemodynamic, and therapeutic characteristics, with unique additions or omissions depending on the clinical contexts. Nomenclature for RHF was variable, and only 40% of articles articulated a narrative definition.

At this time, development of consistent criteria and a universal definition for RHF remains a work in process.