Related Experiment Video
Updated: May 28, 2025

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
Published on: May 21, 2018
Pharma fusion? Don't buy your alliances partners if the goal is breakthrough innovation
Killian McCarthy1, Rick Aalbers2
1Radboud University, Nijmegen, Institute for Management Research, the Netherlands; Kyiv School of Economics, Kyiv, Ukraine.
Abstract:
This paper examines the innovation impact of acquiring alliance partners. We argue that although pre-acquisition alliances might aid post-acquisition integration efforts, by offering insights into targets' proprietary technologies, the familiarity that they foster will also significantly influence the firms post-acquisition innovation outcomes. We tested this using a dataset involving 252 firms, 2398 acquisitions, and 125,440 patents. We found that acquisitions involving former alliance partners increased innovation output. We also found that they fostered the development of more exploitative innovation. However, we found that these transitions inhibit the development of breakthrough innovation by limiting the firm's exposure to novel insights. We conclude, therefore, that alliance partner acquisitions are far from an innovation panacea for the pharm industry.
More Related Videos
Related Concept Videos
Drug Discovery: Overview
Drug Administration and Therapy Phases: Overview
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Clinical Trials: Overview
Prodrugs
Prodrugs help overcome...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Biopharmaceutics and Pharmacokinetics: Overview

