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Non-coding RNA as a key regulator and novel target of apoptosis in diabetic cardiomyopathy: Current status and future
Yicheng Liu1, Jie Yuan2, Yuhang Zhang1
1College of Rehabilitation Medicine，Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Abstract:
The occurrence of diabetic cardiomyopathy (DCM) can be independent of several risk factors such as hypertension and myocardial ischemia, which can lead to heart failure, thus seriously threatening human health and life. Sustained hyperglycemic stimulation can induce cardiomyocyte apoptosis, which is recognized as the pathological basis of DCM. It has been demonstrated that dysregulation induced by apoptosis is closely associated to progression of DCM, but mechanisms behind it requires further clarification. Currently, increasing evidence has shown that non-coding RNA (ncRNA), especially microRNA, long-chain non-coding RNA (lncRNA), and circular RNA (circRNA), play a regulative role in apoptosis, thus affecting the progression of DCM. Notably, some ncRNAs have also exhibit potential significance as biomarkers and/or therapeutic targets for patients with DCM. In this review, recent findings regarding the potential mechanisms of ncRNA in regulating apoptosis and their role in the progression of DCM were systematically summarized in this research. The conclusion reveals that ncRNA abnormalities exert a crucial role in pathological changes of DCM, which offers potential therapeutic targets for the prevention of DCM.
Insights
Diabetic cardiomyopathy (DCM) involves heart cell death, and non-coding RNAs (ncRNAs) are key regulators. Understanding ncRNA roles in apoptosis offers new therapeutic targets for DCM prevention.
Area of Science:
- Cardiology
- Molecular Biology
- Genetics
Background:
- Diabetic cardiomyopathy (DCM) is a serious complication of diabetes, leading to heart failure.
- Hyperglycemia induces cardiomyocyte apoptosis, a primary driver of DCM pathology.
- The precise mechanisms linking apoptosis dysregulation to DCM progression require further investigation.
Purpose of the Study:
- To systematically review the role of non-coding RNAs (ncRNAs) in regulating apoptosis in DCM.
- To explore the potential of ncRNAs as biomarkers and therapeutic targets for DCM.
Main Methods:
- Literature review of recent findings on ncRNA mechanisms in apoptosis and DCM progression.
- Systematic summary of evidence linking ncRNA abnormalities to DCM pathogenesis.
Main Results:
- Non-coding RNAs, including microRNAs, lncRNAs, and circRNAs, significantly regulate cardiomyocyte apoptosis.
- Dysregulation of ncRNAs is closely associated with the progression of DCM.
- Certain ncRNAs show promise as diagnostic biomarkers and therapeutic targets for DCM.
Conclusions:
- Abnormalities in ncRNA expression play a critical role in the pathological changes observed in DCM.
- Targeting ncRNAs offers potential therapeutic strategies for preventing and treating DCM.
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