Related Experiment Video
Updated: May 28, 2025
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
10.9K
Vitamin D Supplementation, Chronic Obstructive Lung Disease and Asthma Exacerbations, and Lung Function Decline
Diane R Gold1, Vincent J Carey2, Craig P Hersh2
1The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States; The Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
The Journal of Nutrition
|February 8, 2025
Summary
Vitamin D supplementation did not reduce exacerbations or improve lung function in individuals with COPD or asthma. This study found no significant benefit for respiratory health in adults without vitamin D deficiency.
Area of Science:
- Respiratory medicine
- Nutritional science
- Clinical trials
Background:
- Acute exacerbations of chronic obstructive lung disease (COPD) and asthma significantly contribute to global disease burden.
- The efficacy of vitamin D supplementation in reducing these exacerbations remains uncertain.
Purpose of the Study:
- To evaluate the effect of vitamin D supplementation versus placebo on acute COPD and asthma exacerbations.
- To assess the impact of vitamin D on pulmonary function, specifically airflow obstruction decline.
Main Methods:
- The Lung VITamin D and OmegA-3 TriaL (VITAL) study enrolled over 3600 participants at risk for respiratory exacerbations.
- Participants received vitamin D3 (2000 IU/d) or placebo, with follow-up for 5 years via questionnaires and spirometry for a subset.
Main Results:
- Vitamin D supplementation showed no association with a reduced risk of COPD or asthma exacerbations.
- No significant difference was observed in the rate of COPD exacerbations between vitamin D and placebo groups.
- Supplementation did not slow the decline in forced expiratory volume in 1 second (FEV1) over the 2-year follow-up.
Conclusions:
- Vitamin D supplementation, compared to placebo, did not lower COPD exacerbation rates or enhance pulmonary function in adults without vitamin D deficiency.
- The findings suggest vitamin D supplementation is not beneficial for preventing respiratory exacerbations or maintaining lung function in this population.
More Related Videos
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
174
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
174
01:23Role of Skin in Vitamin D Synthesis
5.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.0K
01:22Chronic Obstructive Pulmonary Disease
1.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.1K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:29Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.7K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.7K