Exploring 4-quinolone-3-carboxamide derivatives: A versatile framework for emerging biological applications

4-Quinolones are a pivotal class of compounds derived from the quinoline core, recognized for their broad therapeutic applications. Originating from the synthesis of chloroquine, their discovery led to nalidixic acid, the first quinolone analog to exhibit antibacterial activity, catalyzing the development of fluoroquinolones. Beyond their role as antibiotics, 4-quinolone derivatives have emerged as versatile scaffolds with demonstrated antitumor, antiviral, and antiparasitic activities, among others. Concurrently, the carboxamide functional group has gained prominence in medicinal chemistry due to its structural versatility and bioisosteric potential. Its unique properties, such as conformational stability and dual hydrogen bond capabilities, enable diverse pharmacodynamic interactions. The combination of these two structural fragments has proven to be a powerful tool for the discovery of new bioactive prototypes. This review consolidates advancements in the exploration of 4-quinolone-3-carboxamide derivatives, emphasizing their multifaceted biological activities and the innovative strategies driving their optimization. Key highlights include their potential as kinase inhibitors, antiviral agents, and anticancer therapeutics. By synthesizing insights from recent studies, this review underscores the relevance of this framework in addressing contemporary medicinal challenges.